Cardiac CT imaging in coronary artery disease: Current status and future directions

Computed tomography has undergone rapid developments over the last decades, in particular, the emergence and technological improvements of multislice CT scanners enable satisfactory performance of cardiac CT imaging. Cardiac CT has been widely used in the diagnosis of coronary artery disease, which is the leading cause of death in industrialized countries. Cardiac CT also provides valuable information to predict the extent and prognosis of coronary artery disease. The main disadvantage of cardiac CT imaging is radiation dose, which raises concern in recent years, as there is potential risk of radiation-induced malignancy. This article will provide an overview of the current research status of cardiac CT imaging in the diagnosis of coronary artery disease, highlight the key applications of cardiac CT imaging and briefly discuss future directions of this fast advancing technique

Coronary CT angiography in coronary artery disease: Opportunities and challenges

Coronary CT angiography is widely recognised as a reliable imaging modality for the diagnosis of coronary artery disease. Coronary CT angiography not only provides excellent visualisation of anatomical changes in the coronary artery with high diagnostic value in the detection of lumen stenosis or occlusion, but also offers quantitative characterisation of coronary plaque components. Furthermore, coronary CT angiography allows myocardial perfusion imaging with diagnostic value comparable to the reference standard method. Coronary CT angiography-derived haemodynamic analysis has the potential to evaluate functional significance of coronary lesions. This review article aims to provide an overview of clinical applications of coronary CT angiography in coronary artery disease

Multislice CT angiography in coronary artery disease: Technical developments, radiation dose and diagnostic value

Multislice computed tomography (CT) angiography has been increasingly used in the detection and diagnosis of coronary artery disease because of its rapid technical evolution from the early generation of 4-slice CT scanners to the latest models such as 64-slice, 256-slice and 320-slice CT scanners. Technical developments of multislice CT imaging enable improved diagnostic value in the detection of coronary artery disease, and this indicates that multislice CT can be used as a reliable less-invasive alternative to invasive coronary angiography in selected patients. In addition, multislice CT angiography has played a significant role in the prediction of disease progression and cardiac events. Despite promising results reported in the literature, multislice CT has the disadvantage of having a high radiation dose which could contribute to the radiation-induced malignancy. A variety of strategies have been currently undertaken to reduce the radiation dose associated with multislice CT coronary angiography while in the meantime acquiring diagnostic images. In this article, the author will review the technical developments, radiation dose associated with multislice CT coronary angiography, and strategies to reduce radiation dose. The diagnostic and prognostic value of multislice CT angiography in coronary artery disease is briefly discussed, and future directions of multislice CT angiography in the diagnosis of coronary artery disease will also be highlighted

Three-Dimensional Visualization of Suprarenal Aortic Stent-Grafts: Evaluation of Migration in Midterm Follow-up

Purpose: To investigate the midterm results of transrenal fixation of abdominal aortic stent-grafts with regard to device migration and encroachment of stent wires on the renal and visceral branches.Methods: Imaging data from 18 patients (15 men; mean age 75 years, range 63 84) undergoing transrenal stent-graft fixation for abdominal aortic aneurysm (AAA) were included in the study. Computed tomographic angiographic data acquired within 1 week of stent-graft implantation were compared to the latest follow-up images. Postprocessing methods generated 3-dimensional (3D) maximum intensity projections (MIP) and virtual intravascular endoscopy (VIE) for evaluation of the relationship between suprarenal stents and aortic branches. Aortic neck angulation was measured in each patient for correlation with the incidence of stent migration.Results: The mean follow-up period was 40 months. 3D image visualizations showed that the stent-graft moved caudally in all patients (range 2.6 14.2 mm), with migration (>10 mm) observed in 4 (22%) patients. Corresponding VIE images documented changes in stent wire encroachment on the aortic branch ostia in 11 patients, including the number and position of crossing stent wires. There was no close relationship between aortic neck angulation and stent migration.Conclusion: The current study demonstrated that migration occurs at midterm follow-up in transrenally deployed stent-grafts. 3D images were valuable for the assessment of stent migration, as well as its relationship with aortic branch ostia. Long-term follow-up of transrenal fixation deserves to be investigated, especially after observing stent migration relative to aortic ostial encroachment

Insights into 3D printing in medical applications

Three-dimensional (3D) printing has been increasingly used in the medical field with reported applications showing great value in assisting clinical decision-making and improving patient care (1-10). Patient-specific 3D printed models derived from medical imaging datasets, mainly from computed tomography (CT) and magnetic resonance imaging (MRI) are shown to play an important role in pre-surgical planning and simulation of complex surgical procedures, medical education and patient-doctor communication (1-14)